C Ronald Kahn Selected Research

Insulin (Novolin)

6/2022	Correction to: Defining the underlying defect in insulin action in type 2 diabetes.
1/2022	Insulin action in the brain: cell types, circuits, and diseases.
10/2021	Differential roles of FOXO transcription factors on insulin action in brown and white adipose tissue.
10/2021	Insulin action at a molecular level - 100 years of progress.
1/2021	Defining the underlying defect in insulin action in type 2 diabetes.
11/2020	Muscle-Specific Insulin Receptor Overexpression Protects Mice From Diet-Induced Glucose Intolerance but Leads to Postreceptor Insulin Resistance.
1/2020	Fructose and hepatic insulin resistance.
12/2019	Identification of two microRNA nodes as potential cooperative modulators of liver metabolism.
1/2019	Multi-dimensional Transcriptional Remodeling by Physiological Insulin In Vivo.
1/2019	Insulin action in the brain regulates mitochondrial stress responses and reduces diet-induced weight gain.

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C Ronald Kahn Research Topics

Disease

100	Insulin Resistance 01/2022 - 01/2002
43	Obesity 01/2022 - 04/2002
35	Type 2 Diabetes Mellitus (MODY) 06/2022 - 01/2003
17	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2022 - 07/2004
17	Glucose Intolerance 10/2021 - 07/2002
17	Hyperinsulinism (Hyperinsulinemia) 01/2021 - 12/2002
11	Inflammation (Inflammations) 01/2021 - 06/2004
10	Hyperglycemia 02/2014 - 12/2002
8	Weight Gain 01/2021 - 11/2007
8	Lipodystrophy 01/2021 - 02/2004
7	Hyperplasia 01/2019 - 10/2003
7	Body Weight (Weight, Body) 01/2019 - 07/2002
7	Fatty Liver 11/2017 - 02/2004
6	Neoplasms (Cancer) 11/2012 - 04/2002
5	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 10/2021 - 04/2010
5	Hypoglycemia (Reactive Hypoglycemia) 05/2015 - 01/2002
4	Mitochondrial Diseases (Mitochondrial Disease) 01/2021 - 11/2013
4	Fibrosis (Cirrhosis) 01/2021 - 10/2011
4	Liver Diseases (Liver Disease) 12/2020 - 08/2007
4	Non-alcoholic Fatty Liver Disease 01/2020 - 01/2016
4	Metabolic Diseases (Metabolic Disease) 01/2017 - 02/2008
4	Alzheimer Disease (Alzheimer's Disease) 10/2015 - 03/2004
3	Cardiomegaly (Heart Hypertrophy) 01/2021 - 12/2007
3	Hypertriglyceridemia 01/2021 - 07/2004
3	Hypertrophy 01/2019 - 12/2007
3	Carcinogenesis 01/2019 - 06/2010
3	Muscular Atrophy (Muscle Atrophy) 01/2019 - 06/2010
3	Neurodegenerative Diseases (Neurodegenerative Disease) 10/2015 - 03/2004
3	Hypoxia (Hypoxemia) 06/2010 - 08/2003
3	Heart Failure 05/2010 - 03/2007
2	SHORT syndrome 01/2017 - 07/2013
2	Wounds and Injuries (Trauma) 07/2015 - 05/2012
2	Exocrine Pancreatic Insufficiency 01/2013 - 01/2010
2	Hypercholesterolemia 04/2012 - 05/2005
2	Abdominal Obesity 04/2012 - 08/2007
2	Ketosis 12/2011 - 01/2003

Drug/Important Bio-Agent (IBA)

103	Insulin (Novolin)FDA Link 06/2022 - 01/2002
53	Glucose (Dextrose)FDA LinkGeneric 01/2021 - 01/2002
46	Insulin ReceptorIBA 10/2021 - 07/2002
13	Proteins (Proteins, Gene)FDA Link 01/2022 - 01/2003
13	LipidsIBA 01/2021 - 08/2007
11	Insulin-Like Growth Factor I (IGF-1)IBA 01/2019 - 06/2003
10	LeptinIBA 01/2017 - 04/2002
9	Phosphotransferases (Kinase)IBA 01/2021 - 02/2005
8	Triglycerides (Triacylglycerol)IBA 07/2011 - 07/2002
7	MicroRNAs (MicroRNA)IBA 01/2022 - 08/2014
7	EnzymesIBA 01/2020 - 07/2003
6	CholesterolIBA 01/2021 - 07/2008
6	Messenger RNA (mRNA)IBA 01/2019 - 03/2003
5	Fatty Acids (Saturated Fatty Acids)IBA 01/2020 - 07/2004
5	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 01/2019 - 09/2003
5	Transcription Factors (Transcription Factor)IBA 01/2019 - 10/2004
5	Phosphatidylinositols (Phosphatidylinositol)IBA 01/2017 - 01/2002
5	CytokinesIBA 01/2016 - 06/2004
5	Insulin-Like PeptidesIBA 01/2016 - 03/2007
5	PPAR gammaIBA 05/2009 - 03/2003
4	Insulin Receptor Substrate ProteinsIBA 01/2020 - 06/2003
4	FructoseIBA 01/2020 - 05/2016
4	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 04/2016 - 04/2009
4	Tyrosine (L-Tyrosine)FDA Link 01/2009 - 06/2004
4	Sterol Regulatory Element Binding Protein 1IBA 07/2006 - 07/2004
3	Biomarkers (Surrogate Marker)IBA 01/2022 - 11/2010
3	Blood Glucose (Blood Sugar)IBA 10/2021 - 01/2016
3	IGF Type 1 Receptor (IGF 1 Receptor)IBA 10/2021 - 03/2002
3	Amino Acids FDA Link 01/2021 - 02/2005
3	AdiponectinIBA 01/2021 - 11/2003
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2020 - 12/2007
3	Hypoglycemic Agents (Hypoglycemics)IBA 10/2017 - 08/2003
3	Hormones (Hormone)IBA 02/2014 - 11/2005
3	AntioxidantsIBA 11/2013 - 04/2002
3	Sirtuin 3IBA 10/2011 - 02/2011
3	Stearoyl-CoA DesaturaseIBA 10/2011 - 05/2005
3	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 10/2011 - 08/2003
3	Suppressor of Cytokine Signaling ProteinsIBA 10/2005 - 06/2004
2	Amylases FDA Link 01/2022 - 01/2013
2	Vancomycin FDA LinkGeneric 01/2022 - 12/2018
2	Interleukin-6 (Interleukin 6)IBA 01/2021 - 04/2006
2	RNA (Ribonucleic Acid)IBA 01/2021 - 12/2019
2	LipofuscinIBA 12/2020 - 01/2020
2	ketohexokinaseIBA 01/2020 - 11/2017
2	Liver GlycogenIBA 01/2020 - 12/2005
2	Non-Receptor Type 1 Protein Tyrosine PhosphataseIBA 01/2020 - 08/2007
2	Dietary SugarsIBA 01/2020 - 10/2019
2	Protein Isoforms (Isoforms)IBA 01/2019 - 04/2009
2	Anti-Bacterial Agents (Antibiotics)IBA 12/2018 - 12/2016
2	Pro-Opiomelanocortin (Proopiomelanocortin)IBA 10/2017 - 06/2007
2	CorticosteroneIBA 07/2017 - 05/2005
2	Arginine (L-Arginine)FDA Link 01/2017 - 02/2005
2	Bile Acids and Salts (Bile Acids)IBA 12/2016 - 07/2008
2	Dietary Fats (Dietary Fat)IBA 05/2016 - 05/2005
2	AdipokinesIBA 01/2016 - 04/2004
2	Protein Kinase CIBA 12/2015 - 04/2012
2	Reactive Oxygen Species (Oxygen Radicals)IBA 03/2015 - 08/2011
2	Streptozocin (Streptozotocin)FDA Link 02/2015 - 09/2004
2	CarbohydratesIBA 02/2014 - 04/2012
2	Lipase (Acid Lipase)FDA Link 01/2013 - 01/2010
2	EstersIBA 01/2013 - 01/2010
2	GlucocorticoidsIBA 11/2012 - 12/2007

Therapy/Procedure

9	Therapeutics 01/2022 - 08/2002
3	Caloric Restriction 09/2012 - 12/2007